Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32
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چکیده
منابع مشابه
on some bayesian statistical models in actuarial science with emphasis on claim count
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15 صفحه اولRegulation of the Expression of GARP/Latent TGF-b1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation
GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-b1. We find that GARP and latent TGF-b1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL...
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Neoadjuvant chemotherapy (NACT) has been an increasingly used therapeutic strategy to improve the outcome of advanced gastric cancer (GC) over the past few decades. Lymphocytic infiltration has been reported to be associated with response to NACT, but the immune cell subpopulation and its prognosis contributing to response in GC have not been clarified yet. In the current study, the tumor infil...
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Mesenchymal stromal cells (MSCs) represent a promising tool for therapy in regenerative medicine, transplantation, and autoimmune disease due to their trophic and immunomodulatory activities. However, we are still far from understanding the mechanisms of action of MSCs in these processes. Transforming growth factor (TGF)-β1 is a pleiotropic cytokine involved in MSC migration, differentiation, a...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2021
ISSN: 1672-7681,2042-0226
DOI: 10.1038/s41423-021-00701-z